|
Type A
|
Code |
Competences Specific |
| |
Research |
| |
AR18 |
Understanding gene expression, function of DNA and its derived processes. |
| |
AR19 |
Understanding the role of proteins, enzymes and antibodies in the body and how the properties of the antibodies can be exploited for diagnostic and therapeutic use. |
| |
AR21 |
Understanding genomics, transcriptomics and proteomics and the tools that are used to study each one. |
|
Type B
|
Code |
Competences Transversal |
| |
Research |
| |
BR2 |
Treballar de manera autònoma amb iniciativa. |
| |
BR4 |
Capacitat d’organització i planificació. |
| |
BR8 |
Capacitat d'apendre |
| |
BR10 |
Habilitats crítiques: anàlisi i sintesi. |
|
Type C
|
Code |
Competences Nuclear |
| |
Common |
| |
CC3 |
Communicating effectively as a professional and as a citizen |
| |
CC4 |
Speaking and understanding a foreign language with complete ease and fluency |
| Objectives |
Competences |
| Understanding the role of proteins, enzymes and antibodies in the body and how the properties of the antibodies can be exploited for diagnostic and therapeutic use. |
AR18
AR19
AR21
|
BR2
BR4
|
|
| Understanding stem cells, differences between embryonic and adult stem cells, and their respective advantages and disadvantages. The methods used for their differentiation and clinical applications. |
|
BR8
BR10
|
CC3
CC4
|
| Topic |
Sub-topic |
| 1- General view of Biochemistry. |
Cellular, chemical and genetic fundamentals of live. Water. Glycids. Lipids. Nucleic acids. |
| 2- Aminoacides, peptides and proteins. |
Amino acides. Peptide bond and primary structure. Three-dimensional structure of proteins. Folding and denaturalization. |
| 3- Methods to study proteins. |
Purification and characterization. Determination of amino acidic sequence. Mass spectrometry. Determination of three-dimensional structure; X ray diffraction and nuclear magnetic resonance. |
| 4- Enzymes. |
Enzymatic catalysis. Michaelis-Menten model. Allosteric enzymes. Enzymatic inhibition. Regulation of enzymatic activity. Catalytic strategies. General view of metabolism. |
| 5- Biomembranes. |
Lipids as a biomembrane components. Proteins as a biomembrane components. Transport and energy transduction. Examples of biomembranes components: membrane transporters, potassium-sodium pump, ATPases, TMS transporters. |
| 6- Nucleic acids. |
Composition and structure of DNA and RNA. Physic and chemical properties. Interactions between proteins and nucleic acids. Special nucleotides: TFOs, TFBs. Hairpins, aODNs, iRNAs, biological applications. |
| 7- Methods to study nucleic acids. |
Electrophoresis. Nucleic acid hybridisation. Enzyme to handle nucleic acids. Polymerase chain reaction (PCR): fundamentals and applications. DNA sequencing. DNA cloning. |
| 8- Micro arrays. |
Types. Construction: lithographic techniques. Applications: gene expression determination, genotyping, SNPs identification, specific binding to transcription factors, identification of protein interactions. |
| Methodologies :: Tests |
| |
Competences |
(*) Class hours |
Hours outside the classroom |
(**) Total hours |
| Introductory activities |
|
1 |
1 |
2 |
| |
| Lecture |
|
20 |
40 |
60 |
| Assignments |
|
5 |
10 |
15 |
| Presentations / expositions |
|
7 |
14 |
21 |
| |
| Personal tuition |
|
8 |
0 |
8 |
| |
| Objective short-answer tests |
|
7 |
0 |
7 |
| Extended-answer tests |
|
6 |
6 |
12 |
| |
(*) On e-learning, hours of virtual attendance of the teacher.
(**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies
| |
Description |
| Introductory activities |
A presentation of the subject which also includes the basic concepts that students should already have acquired in the past. |
| Lecture |
Lecture sessions showing the contents of the course. The lectures will be supported by audiovisual media: presentations power-point with videos and animations. |
| Assignments |
Working in depth a topic by the student.
These works have a direct relationship with the content taught in the master session. Solving exercises. |
| Presentations / expositions |
Presentation and and public defence in class of a topic previously written by students either individually or in groups. |
|
|
|
Description |
| Meetings with students either individually or in small groups to answer questions, indicate areas of improvement and guide the overall development of the subject. |
|
| |
Description |
Weight |
| Assignments |
There will be an oral presentation of a particular topic |
20% |
| Presentations / expositions |
Presentation and and public defence in class of a topic previously written by students either individually or in groups. |
15% |
| Objective short-answer tests |
Two objective tests throughout the course. (first test: 25%) and (second test: 40%) |
65% |
| |
|
Other comments and second exam session |
|
|
| Basic |
NELSON, COX, Lehninger Principles of Biochemistry. 3a edició., Worth Publishers, darrera edició
DEVLIN, T. M., Bioquímica, Ed. Reverté, darrera edició
LODISH, Harvey et al., Biología celular y molecular. 4a ed., Editorial Médica Panamericana, darrera edició
LUQUE, J.; HERRAEZ, A., Biologia Molecular e Ingeniería Genética., Harcourt, darrera edició
McKEE, T., Bioquímica. La base molecular de la vida. 3a edició., McGraw Hill/Interamericana, darrera edició
STRYER, L., Bioquímica., Reverté, darrera edició
|
|
| Complementary |
|
|
(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation. |
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