IDENTIFYING DATA 2019_20
Subject (*) BIOCHEMISTRY Code 13214008
Study programme
Bachelor's Degree in Biochemistry and Molecular Biology (2009)
 Cycle 1st
Descriptors Credits Type Year Period
6 Basic Course First
Language
Anglès
Català
Department Biochemistry and Biotechnology
Medicine and Surgery
Coordinator
ARDÈVOL GRAU, ANA MARIA
PINENT ARMENGOL, MONTSERRAT
FERNÁNDEZ LARREA, JUAN BAUTISTA
TERRA BARBADORA, XIMENA
 E-mail juanbautista.fernandez@urv.cat
ximena.terra@urv.cat
anna.ardevol@urv.cat
montserrat.pinent@urv.cat
ferran.conill@urv.cat
neus.martinez@urv.cat
josep.gomez@urv.cat
carolina.serena@urv.cat
esther.rodriguez@urv.cat
juanmaria.alcaide@urv.cat
nuria.llorens@urv.cat
cristina.torres@urv.cat
veronica.arreaza@urv.cat
antoniojesus.cortes@urv.cat
Lecturers
FERNÁNDEZ LARREA, JUAN BAUTISTA
TERRA BARBADORA, XIMENA
ARDÈVOL GRAU, ANA MARIA
PINENT ARMENGOL, MONTSERRAT
CONILL RIPOLLES, FERRAN
MARTÍNEZ MICAELO, NIEVES BEATRIZ
GÓMEZ ALVAREZ, JOSEP
SERENA PERELLÓ, CAROLINA
RODRÍGUEZ GALLEGO, ESTHER
ALCAIDE HIDALGO, JUAN MARIA
LLORENS POCA, NURIA
TORRES FUENTES, CRISTINA
ARREAZA GIL, VERONICA
CORTÉS ESPINAR, ANTONIO JESÚS
Web
General description and relevant information Set basic concepts which enable to understand how the living beings at the molecular level work.

Competences
Type A Code Competences Specific
 CE2 Describe how living beings function at a basic biochemical, molecular and structural level.
 CE4 Understand organisms at molecular, cellular and metabolic level.
 CE6 Know how to design and apply experimental laboratory protocols, especially in the ambits of biochemistry, microbiology and molecular biology, and to evaluate the risks and safety elements of these protocols.
 CE8 Analyze and interpret data and experimental results in the scientific ambit.
 CE14 Describe how living beings extract, transform and use the energy FROM their surroundings.
Type B Code Competences Transversal
Type C Code Competences Nuclear

Learning outcomes
Type A Code Learning outcomes
 CE2 Comprendre la manera en la qual els éssers vius extreuen, transformen i utilitzen l'energia del seu entorn
Conèixer l'estructura i funcionament a nivell molecular dels diferents sistemes biològics
 CE4 Comprendre la manera en la qual els éssers vius extreuen, transformen i utilitzen l'energia del seu entorn
Conèixer l'estructura i funcionament a nivell molecular dels diferents sistemes biològics
 CE6 Adquirir habilitats pròpies per al treball en el laboratori bioquímic
 CE8 Adquirir habilitats pròpies per al treball en el laboratori bioquímic
Aplicar els coneixements adquirits per solucionar casos pràctics
 CE14 Comprendre com els éssers vius extreuen, transformen i utilitzen l'energia del seu entorn
Type B Code Learning outcomes
Type C Code Learning outcomes

Contents
Topic Sub-topic
1. Introduction to Biochemistry

 Concept and scope of the study of Biochemistry. Levels of study.
Methods of study. Biomolecules
2. Structure of proteins.
 Levels of complexity.
Primary structure, secondary structure, tertiary structure, quaternary structure.
Denaturation and renaturation.
Dynamics of proteins.
3. Enzims Enzymes as biocatalysts.
Factors affecting enzyme activity.
Enzyme-substrate interactions, models. Mechanisms of enzyme catalysis. Enzyme kinetics.
Coenzymes and cofactors
Modulation of enzyme activity.
4. Transmission of information
 Nucleic acids.
DNA replication process.
DNA Transcription.
Protein synthesis: The genetic code. Mechanism of translation. Regulation of gene expression
5. Introduction to Metabolism
 Organization.
Pathways and metabolic cycles.
Anabolism and catabolism.
Control of metabolic flux.
Digestion and absorption of substrates in mammals
6. Bioenergetics
 Thermodynamic and biological systems.
The phosphate group of ATP and energy as intermediaries common.
Coupled reactions.
Substrate level phosphorylation and oxidative phosphorylation.
7. Respiratory chain and oxidative phosphorylation
 Location.
Redox reactions.
Coupling between electron transport and ATP synthesis.
Role of the shuttles.
Electron transport in chloroplasts and photosynthetic phosphorylation.
Photosynthesis. Photosystems.
8. Cycle of tricarboxylic acids
 Central role in the intermediary metabolism.
Reactions of the cycle.
Energy performance.
Anaplerotic reactions.
Cycle regulation
9. Metabolism of glucose
General scheme.
Global energy balance and universal importance.
Stages of glycolysis.
Fermentation.
General regulation and energy efficiency.
Pentose phosphate pathway
Glucids biosynthesis. Gluconeogenesis.
Metabolism of glycogen
Calvin cycle.
10. Lipid Metabolism
 Lipoprotein metabolism. Lipid catabolism.
Beta-oxidation of fatty acids.
Energy efficiency
Ketogenesis.
Lipid biosynthesis.
Lipogenesis.
Cholesterol synthesis.
11. Metabolism of amino acids

 Catabolism. Deamination, transamination and transdeamination
Organification and fixation of nitrogen. Essential amino acids and non-essential. NH3 metabolism.
Urea cycle.
Destination carbonate skeleton of amino acids.
Gluconeogenic and ketogenic amino acids. Amino acids as precursors. Degradation of nucleotides.

Planning
Methodologies  ::  Tests
  Competences (*) Class hours
 Hours outside the classroom
 (**) Total hours
Introductory activities
1 0 1
Lecture
CE2
CE4
CE14
 29 29 58
Seminars
CE4
 11 5.5 16.5
Debates
CE8
 4 4 8
Problem solving, exercises in the classroom
CE4
CE8
 15 15 30
Laboratory practicals
CE6
CE8
 15 15 30
Personal attention
0.25 0 0.25
 
Mixed tests
CE2
CE4
CE6
CE8
CE14
 3 2 5
 
(*) On e-learning, hours of virtual attendance of the teacher.
(**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies
Methodologies
  Description
Introductory activities Activities designed to make contact with students, collect information from them and introduce the subject.
Lecture Description of the contents of the subject.
Seminars In-depth work on a particular topic. Further discussion of the lecture content, which is linked to professional skills.
Debates Activity in which two or more groups defend different opinions on a particular subject.
Problem solving, exercises in the classroom Formulation, analysis, resolution and debate of a problem or exercise related to the topic of the subject
Laboratory practicals Practical application of the theory of a knowledge area in a particular context. Practical exercises in the different laboratories.
Personal attention Practical application of the theory of a knowledge area in a particular context. Practical exercises in the different laboratories.

Personalized attention
Description
Communication and queries by Moodle. Personalized interview at the teacher’s office under a previous appointment through the use of the electronic mail.

Assessment
Methodologies Competences Description Weight        
Debates
CE8
 Debate preparation and participation in the classroom.
15%
Problem solving, exercises in the classroom
CE4
CE8
 The class attendance with the solved problems and the participation at the discussion of these both will be assessed. 15%
Laboratory practicals
CE6
CE8
 Participation at the preparation of the session, resolution of problems related to practice, an evaluation of problems in the classroom.
Assistance is compulsory.
 10%
Mixed tests
CE2
CE4
CE6
CE8
CE14
 Tests that combine questions of development, objective questions, short questions and/or objective tests. 60 %
Others  
 
Other comments and second exam session

There will be two tests during the course, which will all score for the final grade.

The average score of the two mixed tests must reach a minimum grade of 4/10 to add up the remaining grades evaluated.

The second call will consist of a mixed format exam, which will evaluate the content of the entire subject, score 60% of the subject and a minimum grade of 4/10 will also have to be added to add the remaining grades evaluated.

Students who repeat the course and request it explicitly can be evaluated only through the following distribution: 90% Mixed tests + 10% Laboratory practices

Basic rules of application to the biochemistry exams:

  • Students should always do the exam in the indicated classroom (Moodle of the subject).
  • You must bring a calculator.
  • At the start of the exam, you must sit in alternate places, starting at the first row.
  • The exams start at time.
  • You can not take the exams.
  • Tests that have an unintelligible handwriting and if the teacher thinks they are poorly presented, will not be corrected.
  • The mobile phone can not be switched on during the test.
  • You must bring your ID card or equivalent.

In examination tests, all mobile phones, tablets and any other device not specifically allowed for the test must remain switched off and kept out of sight.

The proved fraudulent realization of any examination activity either in material or virtual/electronic format will imply a failing grade of this activity to the student. Notwithstanding, in sight of the gravity of the incident, the Faculty might propose to initiate a disciplinary record, to be ultimately resolved by the rector of the University.

Sources of information

Basic Mathews, van Holde, Ahern, Bioquímica,, última edició disponible,
Stryer, Berg & Tymoczko, Bioquímica, última edició disponible,
Nelson & Cox, Lehninger Principles of Biochemistry, última edició disponible,
Peretó, Fonaments de bioquímica, última edició disponible,
McKee, Bioquímica, las bases moleculares de la vida, última edició disponible,
Campbell & Farrell, Bioquímica. última edició disponible, última edició disponible,
Devlin, Textbook of Biochemistry With Clinical Correlations, última edició disponible,
Pratt, Cornely, Essential Biochemistry, última edició disponible,
Voet & Voet, Biochemistry, última edició disponible,
Elliott & Elliott, Biochemistry and Molecular Biology, última edició disponible,
Koolman, Röhm, Bioquímica: texto y atlas, última edició disponible,
Voet, Voet & Pratt, Fundamentals of Biochemistry: Life at the Molecular Level,, última edició disponible,

- Mathews, van Holde, Ahern.  Bioquímica, última edició disponible. ISBN: 84-7829-053-2

Recursos en línea del llibre: http://www.aw-bc.com/mathews

- Stryer, Berg & Tymoczko. Bioquímica, última edició disponible. ISBN: 978-84-291-7601-8

Recursos en línea del llibre: http://bcs.whfreeman.com/biochem6/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0

- Nelson & Cox. Lehninger Principles of Biochemistry, última edició disponible. ISBN: 0-7167-7108-1

Recursos en línea del llibre: http://bcs.whfreeman.com/lehninger/default.asp?uid=0&rau=0

- Peretó. Fonaments de bioquímica, última edició disponible. ISBN: 84-370-3852-9

- McKee.  Bioquímica, las bases moleculares de la vida, última edició disponible. ISBN: 978-0-053-19-530575-3

- Campbell & Farrell. Bioquímica. última edició disponible. ISBN: 9706863354

- Devlin. Textbook of Biochemistry With Clinical Correlations, última edició disponible. ISBN: 978-0-471-67808-3

Recursos en línea del llibre: http://eu.he.wiley.com/WileyCDA/HigherEdTitle/productCd-0471678082,courseListingNavId-108280,pageType-techsol,page-6.html

- Elliott & Elliott. Biochemistry and Molecular Biology, última edició disponible. ISBN: 0-19-927199-2

Recursos en línea del llibre: http://www.oup.com/uk/orc/bin/9780199271993/

- Koolman, Röhm. Bioquímica: texto y atlas, última edició disponible ISBN: 84-7903-724-5

- Pratt, Cornely. Essential Biochemistry. última edició disponibleISBN: 0-471-39387-8

Recursos en línea del llibre: http://www3.interscience.wiley.com:8100/legacy/college/pratt/0471393878/student/index.html

- Voet & Voet. Biochemistry, última edició disponible. ISBN: 978-0-471-19350-0

Recursos en línea del llibre: http://he-cda.wiley.com/WileyCDA/HigherEdTitle.rdr?productCd=047119350X

- Voet, Voet & Pratt. Fundamentals of Biochemistry: Life at the Molecular Level, última edició disponible. ISBN: 978-0-471-21495-3:

Recursos en línea del llibre: http://he-cda.wiley.com/WileyCDA/HigherEdTitle.rdr?productCd=0471214957

 
Complementary Voet, Voet & Pratt , Fundamentals of Biochemistry: Life at the Molecular Level , última edició disponible ,
Koolman, Röhm , Bioquímica: texto y atlas , última edició disponible ,
Elliott & Elliott , Biochemistry and Molecular Biology , última edició disponible ,

Recommendations


 
Other comments
On the first day of class, it’s explained how the subject does work. Do not study only with presentations used by teachers in class. It is necessary to study with the recommended bibliography too.
(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.