IDENTIFYING DATA 2019_20
Subject (*) CELL BIOLOGY Code 13214006
Study programme
Bachelor's Degree in Biochemistry and Molecular Biology (2009)
Cycle 1st
Descriptors Credits Type Year Period
6 Basic Course First
Language
Català
Department Basic Medical Sciences
Coordinator
GARCÍA SÁNCHEZ, DANIA
E-mail mariaisabel.inza@urv.cat
josefa.girona@urv.cat
kendracatalina.rodriguez@urv.cat
dania.garcias@urv.cat
marta.sanchis@urv.cat
alba.perez@urv.cat
Lecturers
INZA ROJAS, MARÍA ISABEL
GIRONA TELL, JOSEFA
RODRÍGUEZ MOREJON, KENDRA CATALINA
GARCÍA SÁNCHEZ, DANIA
SANCHIS TALÓN, MARTA
PÉREZ CANTERO, ALBA
Web
General description and relevant information This subject is an introduction to the study of cellular organization, both in its structural and functional aspects. The main objective is that the student acquires a conceptual and practical basis on the cellular phenomena that allow him, later, to understand the biochemical foundations of cellular processes and their biotechnological applications. All this knowledge is structured in four thematic blocks: Introduction to Cell Biology, Cytology, Cell Cycle, and Cellular Development.

Competences
Type A Code Competences Specific
 CE4 Understand organisms at molecular, cellular and metabolic level.
 CE8 Analyze and interpret data and experimental results in the scientific ambit.
Type B Code Competences Transversal
Type C Code Competences Nuclear

Learning outcomes
Type A Code Learning outcomes
 CE4 Saber descriure els tipus de cèl·lules i les seves estructures
Saber utilitzar els microscopis òptics i diferenciar en una preparació els diferents tipus cel·lulars
 CE8 Conèixer la utilitat dels diferents tipus de microscopis òptics i electrònics
Conèixer les relacions entre els components cel·lulars i les funcions que realitzen
Type B Code Learning outcomes
Type C Code Learning outcomes

Contents
Topic Sub-topic
BLOCK 1. INTRODUCTION TO BIOLOGY.
CELL BIOLOGY.
Description.
Unit 1. BIOLOGY INTRODUCTION. Biology concepts. Origin of life.

Unit 2. GENERALITIES OF THE CELL. Cell theory. Morphology and composition of the cell. Structural, genetic and physiological properties of the cell. Prokaryotic cells, eukaryotic cells and viruses.

Unit 3. FUNDAMENTAL FUNCTIONS OF LIVING ORGANISMS. Metabolism: nutrition, respiration and synthesis. Self-perpetuation: homeostasis, reproduction and adaptation.
BLOCK 2. CITOLOGY. Description. Unit 4. STUDY METHODS OF THE CELL (I) ELECTRICAL AND ELECTRONIC MICROSCOPE. Historical introduction to the study of cells. Types of microscopes and their applications. Techniques of preparation of the biological material.

Unit 5. STUDY METHODS OF THE CELL (II). Cell splitting. Cell cultures. Techniques of localization microscopy of specific molecules: Cytochemistry, immunocytochemistry and autoradiography.

Unit 7. PLASMATIC MEMBRANE. Structure. Chemical composition and molecular organization. Physiological activity: permeability. Specializations of the surface. Biogenesis.

Unit 8. EXTRACELLULAR MATRIX AND ITS RECEPTORS. The matrix to animal cells: components and organisation. The matrix to the plant cells: the cellular wall.

Unit 9. CYTOPLASMATIC MATRIX. Structure. Chemical composition. Physiological activity.

Unit 10. CYTOSKELETON. General organization and constituent elements. Microtubules: organization and dynamics. Organizing centers of microtubules: centrioles, basal corpuscles and centromeres. Microtubular structures: achromatic spindle, cilia and flagella. Microfilaments: organization and dynamics. Intermediate filaments: diversity and organization. Interactions between the different components of the cytoskeleton. Fundamentals of cellular movement.

Unit 11. ENDOPLASMATIC RETICULUM. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 12. GOLGI COMPLEX. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 13. LYSOSOMES AND ENDOSOMES. Types. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 14. PEROXISOMES. Types. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 15. MITOCHONDRIA. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 16. PLASTIDS: chloroplasts. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 17. INTERPHASE NUCLEI: nuclear envelope. Structure. Chemical composition. Physiological activity. Biogenesis.

Unit 18. INTERPHASE NUCLEI: nuclear matrix. Composition and organisation of genetic material: chromatin.

Unit 19. INTERPHASE NUCLEI: nucleolus. Structure. Molecular organisation. Physiological activity. Biogenesis.

Unit 20. RIBOSOMES. Structure. Chemical composition. Role in protein biosynthesis. Biogenesis.

BLOCK 3. CELL CYCLE AND DEVELOPMENT. Description. Unit 21. CELL CYCLE. Change and cell growth. Stages and cell cycle regulation. Aging and cell death.

Unit 22. CELL DIVISION (I): Mitosis. Overview. Molecular organisation and functional role of the mitotic apparatus.

Unit 23. CELL DIVISION (II): meiosis and gametogenesis. Overview. Nuclear and cytoplasmic changes during gametogenesis. Structure of egg and sperm.

Unit 24. FERTILIZATION. Description of the process of fertilisation. Activation of the egg. Specific egg-sperm receptor.

Unit 25. FEATURES STAGES OF EMBRYONIC DEVELOPMENT. Segmentation, blastula, gastrula. Nucleo-cytoplasmic interactions during development. Neurulation and embryonic induction. Cell differentifeatation. Training pattern.
BLOCK OF PRACTICES. Practices. Practice 1. Introduction to the optical and stereo microscopy and how does it work.

Practice 2. Introduction to electron microscopy and how does it work.

Practice 3. Introduction to the cell structure (I): Differences between eukaryotic and prokaryotic organisms.

Practice 4. Introduction to the cell structure (II): Differences between animal and plant cells.

Practice 5. Introduction to the cell structure (I): microscopic fungi.

Practice 6. Cell division processes: mitosis.

Practice 7. Cell division processes: meiosis.

Practice 8. Gametogenesis: spermatogenesis and oogenesis.

Practice 9. KARYOTYPE: study of human chromosomes. Interests and application.

Practice 10. Blood groups determination. Application of genetic problems.

Planning
Methodologies  ::  Tests
  Competences (*) Class hours
Hours outside the classroom
(**) Total hours
Introductory activities
CE4
1 0 1
Lecture
CE4
CE8
28 42 70
Laboratory practicals
CE4
CE8
24 10 34
Seminars
CE4
CE8
14 24 38
Personal attention
CE4
CE8
2 0 2
 
Mixed tests
CE4
CE8
5 0 5
 
(*) On e-learning, hours of virtual attendance of the teacher.
(**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies
Methodologies
  Description
Introductory activities General presentation of the subject
Lecture Theoretical explanation of the subject in the classroom for 2 hours per week distributed according to the official schedule. Each lesson classes will last 50 minutes.
Laboratory practicals The practical classes are mandatory. They will last 21 hours, distributed in three hours per day for 7 days according to the set schedule. The practical sessions are oriented in such a way that allows the student a better understanding of the theoretical part of the program. They also cover aspects that are more superficially treated in the theoretical classes.
Prerequisites:
1) students must wear a lab coat and the practice script that they can acquire via MOODLE
2) before each practice the student will have to read the protocol of this carefully; this will allow making the most of your knowledge, and to answer the corresponding questionnaire.
Important notice: Those students who will lose more than two practices without just cause, will be performing a personalized examination (see assessment). This will not exempt you from the final practical exam, as it is only one way to evaluate the pra
Seminars The Seminars will consist of presentations in the PowerPoint format that students will do in groups of 3 or 4 about a recent publication that evaluates aspects related to the contents of the theoretical subjects. The members of each working group, as well as the corresponding papers, will be assigned by the teachers in charge of seminars.
The presentation must include:
- Introduction
- Article content
- The problem that is posed
- Results obtained
Personal attention

Personalized attention
Description
The student is encouraged to use personalized attention. Consult your questions directly with the professors, either jointly with other classmates or in a personalized interview, but with a date agreed in advance. Given that the teachers of this subject have their offices in the Faculty of Medicine of Reus, we recommend that students make personalized attention by email at any time during the course.

Assessment
Methodologies Competences Description Weight        
Laboratory practicals
CE4
CE8
The practical sessions will be evaluated through the attendance, which is mandatory for all the students except for those students who have failed to pass the subject, and through a practical test or practical exercise that will be done on the last day of the laboratory session. If you do not attend practical sessions you will not be able to evaluate the subject in any examination call and will be considered NOT PRESENTED. You must attend 100% of the practical lessons. However, those students who have missed more than two practices for justified causes will be given an additional test exclusively from these parts of the program. 10%
Seminars
CE4
CE8
The Seminars will consist of oral presentation that will be made by students in groups of 3 or 4 about a recent publication. The members of each working group, as well as the publication, will be assigned by the teachers in charge of the seminars. These publications will increase with practical examples, the contents explained in the theoretical lessons. Each component of the group must present a part of the work to be evaluated. Teachers and classmates may ask about the exposed work. Evaluation of the exposition represent 10% of the seminar mark. At the end of each seminar, there will be an evaluation of the topic developed that will consist of 5 True / False questions (10 minutes to answer) (10% seminars mark). The mark of the seminars will be kept during the following academic year for the repeating students, and for a single time. 20%
Mixed tests
CE4
CE8
The contents of the program explained in the lectures will be evaluated through a partial exam and a final or synthesis exam that must be passed with a minimum mark of 5 out of 10 to be considered passed. The exams will include questions like tests, short questions or illustrated problems about the thematic blocks. Students who have passed the partial exam will not have to examine this part of the contents in the final exam.
The final mark of the theoretical subjects will be the one derived from the average of the two exams passed (70%) plus the mark obtained in the seminars (20%) plus the practical question (10%). If someone fail the evaluation (partial and / or final) the final mark will be suspended only if obtained from the average of both exams extrapolated to 70%.
Those students who have not passed one of the examinations will have the opportunity to take a review of the content suspended (second call). The second call will have the same structure that the final exam. As in other evaluations, it must be passed with a minimum mark of 5 out of 10. If not, the final mark will be only the mark obtained in the theoretical exams (extrapolated to its value of 70%) and neither the practical nor seminar notes will be added.
70%
Others  

Repeating students will not have to repeat the practical lessons if they were attended all the sessions, but they would be examined about practical contents if they failed the practical test in the previous course. Likewise, it will not be necessary to do the seminars again and the mark will be saved only during the following academic year. The passed partial notes of the theoretical contents are not saved for the following academic year.

 
Other comments and second exam session

Although this course is not offered in English, foreign exchange students will receive personalised support in English and will be able to develop the evaluation activities in this language.

With the spirit of orienting the student to obtain the optimal results (maximum grade), we recommend following these suggestions:

1. When the student is asked about a concept, then is expected to answer 3 basispoints:

a. What is? (structure, composition, specific process that is carried out)

b. Where is it? (location of the structure or process) and

c. What is it for? (the specific function of the part, stage or process)

Likewise, and if applicable, it is expected that you put a specific example or make a drawing if relevant.

2. If the question recommends answer with a diagram or with a schematic drawing,it is important to do so clearly and comprehensively.

If it is appropriate it will be complemented with a brief explanation.

3. Students who want to review their exam will have to bring their notes in order to be able to verify and more accurately evaluate the reason for the mark obtained.

During the exams, mobile phones, tablets, andother devices that are not expressly authorized for the test, must be turnedoff and out of sight.

The demonstrable fraudulent activity during any evaluation, both in manuscript material, virtual or electronic support, entails the student's suspense note of this evaluation activity. Regardless of this,given the seriousness of the events, the centre may propose the initiation of a disciplinary file, which will be opened by resolution of the rector.


Sources of information

Basic PANIAGUA, R. & cols., Biología celular, 2ª ed. McGraw-Hill Interamericana, Madrid (2003)
KARP, G. , Biología celular y molecular , 4ª ed. McGraw-Hill Interamericana, Mèxic (2005)
Lodish, H. et al., Biología celular y molecular , 5ª ed. Panamericana , Barcelona (2005)
Gilbert , Biología del desarrollo , 7ª ed. Panamericana , Barcelona (2005)
ALBERTS, B., D. BRAY, J. LEWIS, M. RAFF, K. ROBERTS & J.D. WATSON , Biología molecular de la célula , 4ª ed. Omega, Barcelona (2004)
ALBERTS, B., BRAY D., JOHNSON A., LEWIS J., RAFF M., ROBERTS K., WALTER P. , Introducción a la Biología Celular , 2ª ed. Panamericana , Barcelona (2006










































 












Complementary

Recommendations


(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.