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Type A
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Code |
Competences Specific | | | CE8 |
Analyze and interpret data and experimental results in the scientific ambit. |
| | CE9 |
Have structural and functional knowledge of the basic components and polymeric structures of molecules in living beings. |
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Type B
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Code |
Competences Transversal |
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Type C
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Code |
Competences Nuclear |
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Type A
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Code |
Learning outcomes |
| | CE8 |
Use different databases (e.g., PDB, SCOP, ...) in order to find out what are the main characteristics of the structure of a specific protein.
Use computer programs to analyze the structure of proteins.
| | | CE9 |
Predict structural information of proteins of which only the sequence is known.
Predict what point mutations should be made in the sequence of a protein to improve its activity at elevated temperatures or at low temperatures. Predict how these mutations would affect the structure of the protein.
Predict what ligands can modulate the activity of a certain protein after reversibly binding.
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Type B
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Code |
Learning outcomes |
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Type C
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Code |
Learning outcomes |
| Topic |
Sub-topic |
| 1. Three-dimensional structure of proteins |
1.1. The SPdbV / SwissModel binomial as computational tools in the field of protein engineering
1.2. Proteins with known structure: analysis of their 3D structure |
| 2. Fundamentals of protein engineering. |
2.1. Application of protein engineering to introduce mutations that improve the thermostability of an enzyme.
2.2. Application of protein engineering in order to introduce mutations that adapt the activity of an enzyme at low temperatures. |
| 3. De novo design of proteins |
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| Methodologies :: Tests |
| |
Competences |
(*) Class hours
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Hours outside the classroom
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(**) Total hours |
| Introductory activities |
|
1 |
0 |
1 |
| IT-based practicals in computer rooms |
|
20 |
25 |
45 |
| Lecture |
|
10 |
15 |
25 |
| Personal attention |
|
2 |
0 |
2 |
| |
| Short-answer objective tests |
|
2 |
0 |
2 |
| |
(*) On e-learning, hours of virtual attendance of the teacher.
(**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. |
Methodologies
| |
Description |
| Introductory activities |
Presentation of the subject (with details of the teaching methodology that will be used and of the evaluation criteria) |
| IT-based practicals in computer rooms |
Practical exercise where, in groups of three or four students, a practical exercise of analysis by computational methods of the structure of a protein will be carried out and they will be asked that, based on this analysis, they suggest what changes are they could perform in their sequence in order to improve some property (eg, thermostability, etc.) with respect to the native protein. |
| Lecture |
Theoretical explanations that will be carried out in the computer room and which will be followed by a practical (non-evaluable) exercise by the students or the visualization of a video in order to exemplify the theoretical explanations |
| Personal attention |
Students can consult their questions directly to the teacher going to their office (at 106) during the visit hours (see institutional website) or also sending an email from moodle. |
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Description |
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Students can consult their questions directly to the teacher going to their office (at 106) during the visit hours (see institutional website) or also sending an email from moodle. |
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Methodologies |
Competences
|
Description |
Weight |
|
|
|
|
| IT-based practicals in computer rooms |
|
Practical exercise where, in groups of three or four students, a practical exercise of analysis by computational methods of the structure of a protein will be carried out and they will be asked that, based on this analysis, they suggest what changes are they could perform in their sequence in order to improve some property (eg, thermostability, etc.) with respect to the native protein |
Aquestes pràctiques poden proporcionar un màxim de 5/10 en la qualificació final de l'assignatura.
Estas prácticas pueden proporcionar un máximo de 5/10 en la calificación final de la asignatura.
These practices can contribute a maximum of 5 points out of 10 to the final grade of the subject. |
| Short-answer objective tests |
|
A single test where the student will have to respond to a series of short objective questions that demonstrate the level of individual benefit that has been achieved in the subject |
Aquesta prova objectiva pot proporcionar un màxim de 5/10 en la qualificació final de l'assignatura.
Esta prueba objetiva puede proporcionar un máximo de 5/10 en la calificación final de la asignatura.
This test can provide a maximum of 5 points out of 10 to the final grade of the subject. |
| Others |
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| |
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Other comments and second exam session |
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In the second call only the equivalent part of the objective tests of short questions of the first call (with identical weight in the final note) will be carried out. This means that the note obtained in the "Practicals using information and communication technologies (ICTs) in computer rooms" section of the first call will be valid also for the second call. During the evaluation tests, mobile phones, tablets and other devices that are not expressly authorized for the test, must be turned off and out of sight. The demonstrable fraudulent realization of some evaluation activity of a subject both in material and virtual and electronic support entails the student's suspense note of this evaluation activity. Regardless of this, given the seriousness of the events, the center may propose the initiation of a disciplinary file, which will be opened by resolution of the rector. |
| Basic |
Lesk, Arthur M., Introduction to protein science: architecture, function, and genomics, 2nd ed., 2010
Edited by Sheldon J. Park, Jennifer R. Cochran, Protein engineering and design, , 2010
Carlos Gómez-Moreno Calera y Javier Sancho Sanz, Estructura de proteínas, , 2003
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| Complementary |
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| Subjects that it is recommended to have taken before |
| STRUCTURE AND FUNCTION OF BIOMOLECULES/13214107 |
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(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation. |
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