| Competences |
| Type A | Code | Competences Specific |
| CE8 | Capacity to understand the principles governing the biology and functioning of the human body in conditions of health and illness in order to analyse and design technological solutions applied in the ambit of health and biomedicine. | |
| Type B | Code | Competences Transversal |
| Type C | Code | Competences Nuclear |
| Learning outcomes |
| Type A | Code | Learning outcomes |
| CE8 |
Understand the way in which living beings extract, transform and use the energy in their environment Understand the molecular structure and function of different biological systems Acquire the skills needed to work in a biochemistry laboratory Use knowledge acquired to solve practical cases | |
| Type B | Code | Learning outcomes |
| Type C | Code | Learning outcomes |
| Contents |
| Topic | Sub-topic |
| 1. Introduction to Biochemistry | Concept and scope of the study of Biochemistry. Levels of study. Methods of study. Biomolecules |
| 2. Structure of proteins. | Levels of complexity. Primary structure, secondary structure, tertiary structure, quaternary structure. Denaturation and renaturation. Dynamics of proteins. |
| 3. Enzymes | Enzymes as biocatalysts. Factors affecting enzyme activity. Enzyme-substrate interactions, models. Mechanisms of enzyme catalysis. Enzyme kinetics. Coenzymes and cofactors Modulation of enzyme activity. |
| 4. Transmission of information | Nucleic acids. DNA replication process. DNA Transcription. Protein synthesis: The genetic code. Mechanism of translation. Regulation of gene expression |
| 5. Introduction to Metabolism | Organization. Pathways and metabolic cycles. Anabolism and catabolism. Control of metabolic flux. Digestion and absorption of substrates in mammals |
| 6. Bioenergetics | Thermodynamic and biological systems. The phosphate group of ATP and energy as intermediaries common. Coupled reactions. Substrate level phosphorylation and oxidative phosphorylation. |
| 7. Respiratory chain and oxidative phosphorylation | Location. Redox reactions. Coupling between electron transport and ATP synthesis. Role of the shuttles. Electron transport in chloroplasts and photosynthetic phosphorylation. Photosynthesis. Photosystems. |
| 8. Cycle of tricarboxylic acids | Central role in the intermediary metabolism. Reactions of the cycle. Energy performance. Anaplerotic reactions. Cycle regulation |
| 9. Metabolism of glucose | General scheme. Global energy balance and universal importance. Stages of glycolysis. Fermentation. General regulation and energy efficiency. Pentose phosphate pathway Glucids biosynthesis. Gluconeogenesis. Metabolism of glycogen Calvin cycle. |
| 10. Lipid Metabolism | Lipoprotein metabolism. Lipid catabolism. Beta-oxidation of fatty acids. Energy efficiency Ketogenesis. Lipid biosynthesis. Lipogenesis. Cholesterol synthesis. |
| 11. Metabolism of amino acids | Catabolism. Deamination, transamination and transdeamination Organification and fixation of nitrogen. Essential amino acids and non-essential. NH3 metabolism. Urea cycle. Destination carbonate skeleton of amino acids. Gluconeogenic and ketogenic amino acids. Amino acids as precursors. Degradation of nucleotides. |
| Planning |
| Methodologies :: Tests | ||||||||||
| Competences | (*) Class hours |
Hours outside the classroom |
(**) Total hours | |||||||
| Introductory activities |
|
1 | 0 | 1 | ||||||
| Lecture |
|
25.75 | 32 | 57.75 | ||||||
| Seminars |
|
11 | 7 | 18 | ||||||
| Problem solving, exercises in the classroom |
|
15 | 15 | 30 | ||||||
| Debates |
|
4 | 4 | 8 | ||||||
| Laboratory practicals |
|
15 | 15 | 30 | ||||||
| Personal attention |
|
0.25 | 0 | 0.25 | ||||||
| Mixed tests |
|
3 | 2 | 5 | ||||||
| (*) On e-learning, hours of virtual attendance of the teacher. (**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | ||||||||||
| Methodologies |
| Description | |
| Introductory activities | Activities designed to make contact with students, collect information from them and introduce the subject. |
| Lecture | Description of the contents of the subject. |
| Seminars | In-depth work on a particular topic. Further discussion of the lecture content, which is linked to professional skills. |
| Problem solving, exercises in the classroom | Formulation, analysis, resolution and debate of a problem or exercise related to the topic of the subject |
| Debates | Activity in which two or more groups defend different opinions on a particular subject. |
| Laboratory practicals | Practical application of the theory of a knowledge area in a particular context. Practical exercises in the different laboratories. |
| Personal attention | Consulta individualitzada per part de l'alumne al professor de dubtes concrets. |
| Personalized attention |
| Description |
| Communication and queries by Moodle. Personalized interview at the teacher’s office under a previous appointment through the use of the electronic mail. |
| Assessment |
| Methodologies | Competences | Description | Weight | ||||
| Problem solving, exercises in the classroom |
|
The class attendance with the solved problems and the participation at the discussion of these both will be assessed. | 15% | ||||
| Debates |
|
Debate preparation and participation in the classroom. | 15% | ||||
| Laboratory practicals |
|
Participation at the preparation of the session, resolution of problems related to practice, an evaluation of problems in the classroom. Assistance is compulsory. |
10% | ||||
| Mixed tests |
|
Les proves inclouran l'avaluació dels continguts donats a la classe magistral, així com dels problemes, pràctiques i seminaris. | 60% | ||||
| Others |
| Other comments and second exam session | |||
|
There will be two tests during the course, which will all score for the final grade. The average score of the two mixed tests must reach a minimum grade of 4/10 to add up the remaining grades evaluated. The second call will consist of a mixed format exam, which will evaluate the content of the entire subject, score 60% of the subject and a minimum grade of 4/10 will also have to be added to add the remaining grades evaluated. Students who repeat the course and request it explicitly can be evaluated only through the following distribution: 90% Mixed tests + 10% Laboratory practices Basic rules of application to the biochemistry exams: • Students should always do the exam in the indicated classroom (Moodle of the subject). • You must bring a calculator. • At the start of the exam, you must sit in alternate places, starting at the first row. • The exams start at time. • You can not take the exams. • Tests that have an unintelligible handwriting and if the teacher thinks they are poorly presented, will not be corrected. • The mobile phone can not be switched on during the test. • You must bring your ID card or equivalent. In examination tests, all mobile phones, tablets and any other device not specifically allowed for the test must remain switched off and kept out of sight. The proved fraudulent realization of any examination activity either in material or virtual/electronic format will imply a failing grade of this activity to the student. Notwithstanding, in sight of the gravity of the incident, the Faculty might propose to initiate a disciplinary record, to be ultimately resolved by the rector of the University. |
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| Sources of information |
| Basic |
Mathews, van Holde, Ahern, Bioquímica, última edició disponible,
Stryer, Berg & Tymoczko, Bioquímica, última edició disponible,
Nelson & Cox, Lehninger Principles of Biochemistry, última edició disponible,
Peretó, Fonaments de bioquímica, última edició disponible,
McKee, Bioquímica, las bases moleculares de la vida, última edició disponible,
Campbell & Farrell, Bioquímica, última edició disponible,
Devlin, Textbook of Biochemistry With Clinical Correlations, última edició disponible,
Elliott & Elliott, Biochemistry and Molecular Biology, última edició disponible,
Koolman, Röhm, Bioquímica: texto y atlas, última edició disponible,
Pratt, Cornely, Essential Biochemistry, última edició disponible,
Voet & Voet, Biochemistry, última edició disponible,
Voet, Voet & Pratt, Fundamentals of Biochemistry: Life at the Molecular Level, última edició disponible, |
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| Complementary | |||||||||
| Recommendations |
| Other comments | |
| On the first day of class, it’s explained how the subject does work. Do not study only with presentations used by teachers in class. It is necessary to study with the recommended bibliography too. |
(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.