| Competences |
| Type A | Code | Competences Specific |
| A4 | Know and understand in an integrated manner the organisms at molecular, cellular and metabolic level. | |
| A6 | Know how to design and apply experimental laboratory protocols in the fields of biotechnology, especially chemical, biochemical, microbiological and molecular biology, assessing their risks and safety elements. | |
| A8 | Analyse appropriately data and experimental results from the fields of biotechnology with statistical techniques and be able to interpret it. | |
| Type B | Code | Competences Transversal |
| Type C | Code | Competences Nuclear |
| Learning outcomes |
| Type A | Code | Learning outcomes |
| A4 |
Describe how living beings extract, transform and use the energy from their environment . Understand the molecular structure and function of the different biological systems. | |
| A6 |
Acquire the skills needed to work in a biochemistry laboratory. | |
| A8 |
Acquire the skills needed to work in a biochemistry laboratory Apply the acquired knowledge to solving practical cases. | |
| Type B | Code | Learning outcomes |
| Type C | Code | Learning outcomes |
| Contents |
| Topic | Sub-topic |
| 1. Biochemistry introduction | Concept and field of study of biochemistry. Study levels. Study methods. Biomolecules. |
| 2. Protein structure | Levels of complexity. Primary structure, secondary structure , tertiary structure, quaternary structure. Denaturation and renaturation. Protein dynamics. |
| 3. Enzyms | Enzymes as biocatalysts. Factors that affect enzymatic activity. Interactions enzyme-substrate, models. Mechanisms of enzymatic catalysis. Enzymatic kinetics. Coenzymes and cofactors. Modulation of enzymatic activity. |
| 4. Genetics | Nucleic acids. DNA replication. DNA repair. Transcription. The genetic code. Mechanism of translation. Regulation of gene expression. |
| 5. Metabolism introduction | Living things as open thermodynamic systems. The phosphate group and the ATP as common energy intermediaries. Reactions coupled. Phosphorylation at the substrate level and oxidative phosphorylation. |
| 6. The energy flow | Living things as open thermodynamic systems. The phosphate group and the ATP as common energy intermediaries. Reactions coupled. Phosphorylation at the substrate level and oxidative phosphorylation. |
| 7. Respiratory chain and oxidative phosphorylation | Location. Oxidoreduction reactions. Coupling between electron transport and ATP synthesis. Role of the shuttles. Transport of electrons in the chloroplast and photosynthetic phosphorylation. Photosynthesis. Photosystems. |
| 8. Cycle of tricarboxylic acids | Central role in the intermediary metabolism. Cycle reactions. Energy efficiency. Anaplelotic reactions. Amphibolic nature of the cycle. Regulation of the cycle. |
| 9. Glucose metabolism | General scheme. Global balance and universal energy importance. Phases of glycolysis. Lactate production. Energy efficiency and general regulation. Via the pentoses. Biosynthesis of carbohydrates. Gluconeogenesis. Metabolism of glycogen Cycle of Calvin. |
| 10. Lipid metabolism | Metabolism of lipoproteins. Lipid catabolism. Betaoxidation of fatty acids. Energy efficiency. Ketogenesis. Lipid biosynthesis. Lipogenesis. Synthesis of fatty acids in prokaryotes. Energetic balance of lipogenesis. Metabolism of isoprenoids. Cholesterol. |
| 11. Amino acids metabolism | Catabolism. Deamination, transamination and trans-deamination. Fixation and organisation of nitrogen. Essential and non-essential amino acids. Metabolism of NH3. Cycle of urea. Destination of carbonate skeleton of amino acids. Gluconeogenic and ketogenic amino acids. Amino acids as precursors. Nucleotides degradation. |
| Planning |
| Methodologies :: Tests | ||||||||||
| Competences | (*) Class hours |
Hours outside the classroom |
(**) Total hours | |||||||
| Introductory activities |
|
1 | 0 | 1 | ||||||
| Lecture |
|
29 | 29 | 58 | ||||||
| Seminars |
|
11 | 5.5 | 16.5 | ||||||
| Debates |
|
4 | 4 | 8 | ||||||
| Problem solving, exercises in the classroom |
|
15 | 15 | 30 | ||||||
| Laboratory practicals |
|
15 | 15 | 30 | ||||||
| Personal attention |
|
0.5 | 0 | 0.5 | ||||||
| Mixed tests |
|
6 | 0 | 6 | ||||||
| (*) On e-learning, hours of virtual attendance of the teacher. (**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | ||||||||||
| Methodologies |
| Description | |
| Introductory activities | Activities designed to make contact with students, collect information from them and introduce the subject. |
| Lecture | Description of the contents of the subject. |
| Seminars | In-depth work on a particular topic. Further discussion of the lecture content, which is linked to professional skills. |
| Debates | Activity in which two or more groups defend different opinions on a particular subject. |
| Problem solving, exercises in the classroom | Formulation, analysis, resolution and debate of a problem or exercise related to the topic of the subject |
| Laboratory practicals | Practical application of the theory of a knowledge area in a particular context. Practical exercises in the different laboratories. |
| Personal attention | Consulta individualitzada per part de l'alumne al professor de dubtes concrets. |
| Personalized attention |
| Description |
| Communication and queries by Moodle. Personalized interview at the teacher’s office under a previous appointment through the use of the electronic mail. |
| Assessment |
| Methodologies | Competences | Description | Weight | ||||
| Debates |
|
Debate preparation and participation in the classroom. | 15 % | ||||
| Problem solving, exercises in the classroom |
|
The class attendance with the solved problems and the participation at the discussion of these both will be assessed. | 15 % | ||||
| Laboratory practicals |
|
Participation at the preparation of the session, resolution of problems related to practice, an evaluation of problems in the classroom. Assistance is compulsory. |
10% | ||||
| Mixed tests |
|
Tests that combine questions of development, objective questions, short questions and/or objective tests. | 60% | ||||
| Others |
| Other comments and second exam session | |||
|
There will be two tests during the course, which will all score for the final grade. The average score of the two mixed tests must reach a minimum grade of 4/10 to add up the remaining grades evaluated. The second call will consist of a mixed format exam, which will evaluate the content of the entire subject, score 60% of the subject and a minimum grade of 4/10 will also have to be added to add the remaining grades evaluated. Students who repeat the course and request it explicitly can be evaluated only through the following distribution: 90% Mixed tests + 10% Laboratory practices Basic rules of application to the biochemistry exams: • Students should always do the exam in the indicated classroom (Moodle of the subject). • You must bring a calculator. • At the start of the exam, you must sit in alternate places, starting at the first row. • The exams start at time. • You can not take the exams. • Tests that have an unintelligible handwriting and if the teacher thinks they are poorly presented, will not be corrected. • The mobile phone can not be switched on during the test. • You must bring your ID card or equivalent. |
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| Sources of information |
| Basic |
Mathews, van Holde, Ahern., Bioquímica, última edició disponible,
Stryer, Berg & Tymoczko, Bioquímica, última edició disponible,
Nelson & Cox, Bioquímica, última edició disponible,
Peretó, Fonaments de bioquímica, última edició disponible,
McKee, Bioquímica, las bases moleculares de la vida, última edició disponible,
Campbell & Farrell, Bioquímica, última edició disponible,
Devlin, Textbook of Biochemistry With Clinical Correlations, última edició disponible,
Pratt, Cornely, Essential Biochemistry, última edició disponible,
Voet & Voet, Biochemistry, última edició disponible, |
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- Mathews, van Holde, Ahern. Bioquímica, última edició disponible. ISBN: 84-7829-053-2 Recursos en línea del llibre: http://www.aw-bc.com/mathews - Stryer, Berg & Tymoczko. Bioquímica, última edició disponible. ISBN: 978-84-291-7601-8 Recursos en línea del llibre: http://bcs.whfreeman.com/biochem6/default.asp?s=&n=&i=&v=&o=&ns=0&uid=0&rau=0 - Nelson & Cox. Lehninger Principles of Biochemistry, última edició disponible. ISBN: 0-7167-7108-1 Recursos en línea del llibre: http://bcs.whfreeman.com/lehninger/default.asp?uid=0&rau=0 - Peretó. Fonaments de bioquímica, última edició disponible. ISBN: 84-370-3852-9 - McKee. Bioquímica, las bases moleculares de la vida, última edició disponible. ISBN: 978-0-053-19-530575-3 - Campbell & Farrell. Bioquímica. última edició disponible. ISBN: 9706863354 - Devlin. Textbook of Biochemistry With Clinical Correlations, última edició disponible. ISBN: 978-0-471-67808-3 Recursos en línea del llibre: http://eu.he.wiley.com/WileyCDA/HigherEdTitle/productCd-0471678082,courseListingNavId-108280,pageType-techsol,page-6.html - Elliott & Elliott. Biochemistry and Molecular Biology, última edició disponible. ISBN: 0-19-927199-2 Recursos en línea del llibre: http://www.oup.com/uk/orc/bin/9780199271993/ - Koolman, Röhm. Bioquímica: texto y atlas, última edició disponible ISBN: 84-7903-724-5 - Pratt, Cornely. Essential Biochemistry. última edició disponibleISBN: 0-471-39387-8 Recursos en línea del llibre: http://www3.interscience.wiley.com:8100/legacy/college/pratt/0471393878/student/index.html - Voet & Voet. Biochemistry, última edició disponible. ISBN: 978-0-471-19350-0 Recursos en línea del llibre: http://he-cda.wiley.com/WileyCDA/HigherEdTitle.rdr?productCd=047119350X - Voet, Voet & Pratt. Fundamentals of Biochemistry: Life at the Molecular Level, última edició disponible. ISBN: 978-0-471-21495-3: Recursos en línea del llibre: http://he-cda.wiley.com/WileyCDA/HigherEdTitle.rdr?productCd=0471214957 |
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| Complementary |
Voet, Voet & Pratt , Fundamentals of Biochemistry: Life at the Molecular Level, , última edició disponible ,
Elliott & Elliott , Biochemistry and Molecular Biology , última edició disponible ,
Koolman, Röhm , Bioquímica: texto y atlas , última edició disponible , |
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| Recommendations |
| Other comments | |
| On the first day of class, it’s explained how the subject does work. Do not study only with presentations used by teachers in class. It is necessary to study with the recommended bibliography too. |