| Competences |
| Type A | Code | Competences Specific |
| A4 | Know and understand in an integrated manner the organisms at molecular, cellular and metabolic level. | |
| Type B | Code | Competences Transversal |
| Type C | Code | Competences Nuclear |
| Learning outcomes |
| Type A | Code | Learning outcomes |
| A4 |
Describe the organisation of information in the genome. Be able to demonstrate having acquired the knowledge related to general Immunology. | |
| Type B | Code | Learning outcomes |
| Type C | Code | Learning outcomes |
| Contents |
| Topic | Sub-topic |
| 1. Introduction to Immunology | - Origin and historical evolution of Immunology - Generalities of the immune system - Immune cells - Immunity innate - Immunity acquired |
| 2. Immune system tissues | - Anatomical organization of the immune system - Primary lymphoid organs - Secondary lymphoid organs - Lymphatic flow |
| 3. Innate immunity and inflammation | - Inflammatory cell component - Soluble factors own to innate immunity - Dynamics and molecular bases of inflammation |
| 4. The complement system | - Components and nomenclature - Activation by the classic way - Activation by the alternative way - Activation via lectins - Membrane attack complex - Effector systems of the complement system - Integration and feedback of the complement system - Acute inflammatory response - Regulation of the Complement |
| 5. Antigens and presentation of antigens | - Concept and properties of antigens - Structure and function of MHC-I and MHC-II - Genetics and MHC polymorphism - Expression of the MHC - Specificity of MHC and initiation of adaptive immunity |
| 6. Repertoire of Ig | - Properties of Ig - Antigen-antibody binding - Genetics of Igs - Ig gene fragments - Somatic recombinations - Diversity of union - Allelic exclusion - Concept of somatic hypermutation and change of isotype |
| 7. Maturation and activation of B-lymphocytes | - Differentiation and maturation of B lymphocytes - B cell markers - Expression of the BCR - Selection of B lymphocytes - Central and peripheral tolerance - Concept of anergy - B lymphocyte subpopulations - Accommodation and circulation of B lymphocytes - T-independent activation of B lymphocytes |
| 8. Maturation and activation of T-lymphocytes | - Gene organization and expression of the TCR - Co-receptors and co-stimulators - Thymic selection and peripheral tolerance - CD4 + / CD8 + differentiation - Immunological synapse |
| 9. Lymphocyte T i B collaboration | - Recognition T-B - T-dependent activation of B cells - Migration of T and B in the follicles - Formation of germinal centers - Proliferation and differentiation B - Switching or Ig isotype change - Maturation of Ig Affinity (Hypermutation) - Differentiation of B lymphocytes - Homing of B cells - Immune memory |
| 10. Cytokines | - Cytokines properties - Cytokines receptors - Cytokines functions - Anti- and proinflammatory cytokines - Regulatory effects of cytokines in adaptive responses |
| 11. Subpopulations of effector T lymphocytes | - Citotoxicity by T-CTL and NK cells - Differentiation Th1, Th2, Th17 and Treg - Effective and regulating functions of subpopulations T |
| Planning |
| Methodologies :: Tests | ||||||||||
| Competences | (*) Class hours |
Hours outside the classroom |
(**) Total hours | |||||||
| Introductory activities |
|
2 | 1 | 3 | ||||||
| Lecture |
|
29 | 50 | 79 | ||||||
| Seminars |
|
9 | 27 | 36 | ||||||
| Laboratory practicals |
|
15 | 3 | 18 | ||||||
| Problem solving, exercises in the classroom |
|
1 | 3 | 4 | ||||||
| Personal attention |
|
1 | 0 | 1 | ||||||
| (*) On e-learning, hours of virtual attendance of the teacher. (**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students. | ||||||||||
| Methodologies |
| Description | |
| Introductory activities | Presentation of the contents of the subject. Explanation of the structure and the selection of the various contents of the subject, and how students will be evaluated and what is required of their immunology learning process. |
| Lecture | Explanation of the syllabus included in the subject programme by .ppt and videos illustrating it. All the material used in class can be found on ''Moodle''. |
| Seminars | Temes monogràfics on es veurà en profunditat com s'integra i coordina el sistema inmune a nivell cel·lular i molecular. Avenços en la Immunologia i aplicacions |
| Laboratory practicals | The laboratory practices will be carried out in laboratories suitable for this purpose. First, an explanation will be provided on the theoretical basis, the objective and the methodology of the practice, which will be carried out in working groups. The practices are compulsory and there are overcome to pass the subject. |
| Problem solving, exercises in the classroom | The teacher provides students with a scientific text, an exercise or a current news to stimulate an argue and debate among the students. |
| Personal attention | At the end of the class, the student can ask the professor specific doubts or concerns regarding the class just given. For those more complex questions the student may agree a time slot with the teacher to meet. There will be no fixed schedule of personalized attention. The student can arrange an appointment with the teacher by e-mail. |
| Personalized attention |
| Description |
| There will be no fixed schedule of personalized attention. The student can arrange an appointment with the teacher by e-mail. |
| Assessment |
| Methodologies | Competences | Description | Weight | ||||
| Lecture |
|
During the course, there will be proposed dates to carry out written tests of the topics developed. It will be necessary to obtain a minimum of 4/10 points to consider this part in the final evaluation of the student | 60% | ||||
| Seminars |
|
Durant el curs es proposaran dates per a realitzar proves escrites amb preguntes/reflexions relatives als temes desenvolupats | 15% | ||||
| Laboratory practicals |
|
At the end of the laboratory practices, the students will carry out a test to demonstrate that they have understood the processes and methodologies applied. | 10% | ||||
| Problem solving, exercises in the classroom |
|
Written tests with questions/reflections related to the developed topics. | 15% | ||||
| Others |
| Other comments and second exam session | |||
| Sources of information |
| Basic |
, , ,
K. Murphy, et al., INMUNOBIOLOGÍA de JANEWAY, última disponible, Masson S.A.
J.R. Regueiro, C. López et al, IMMUNOLOGÍA. BIOLOGÍA Y PATOLOGÍA DEL SISTEMA IMMUNE, Ultima disponible, Médica Panamericana
P. J. Delves, S. J. Martin, D. R. Burton i I. M. Roitt, INMUNOLOGÍA. FUNDAMENTOS, Última disponible, Médica Panamericana
A.k. Abbas i A.W. Lichtman, INMUNOLOGIA CELULAR Y MOLECULAR, Última disponible, Elsevier |
||||||||
| Complementary |
Garlandscience Channel, http:///www.youtube.com/user/garlandscience, ,
, The Journal of Immunology, , The American Association of Immunologists
, Trends in Immunolgy, , Elsevier
, Current Opinion in Immunology, , Elsevier
, Annual Review in Immunology, , Annual Reviews |
||||||||
| Recommendations |
(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.