IDENTIFYING DATA 2013_14
Subject (*) BIOPROCESS ENGINEERING Code 20214210
Study programme
Degree of Agricultural and Food Engineering (2010)
Cycle 1st
Descriptors Credits Type Year Period
6 Optional Second
Language
Anglès
Department Chemical Engineering
Coordinator
KATAKIS ., IOANIS
E-mail ioanis.katakis@urv.cat
Lecturers
KATAKIS ., IOANIS
Web
General description and relevant information This course studies the interface between Chemical Engineering and Microbiology, Biochemistry and Genetic Engineering. Uses quantitative description and mathematical tools for the analysis of the kinetics of biocatalysts (enzymes and cells) and its coupling with transport phenomena and thermodynamics so that the students who finish it be able to design and anlayse bioprocesses with emphasis in the unit operations of reaction and separations/purification.

Competences
Type A Code Competences Specific
 A1.1 Aplicar efectivament el coneixement de les matèries bàsiques, científiques i tecnològiques pròpies de l'enginyeria
Type B Code Competences Transversal
Type C Code Competences Nuclear
 C1.4 Be able to express themselves correctly both orally and in writing in one of the two official languages of the URV

Learning outcomes
Type A Code Learning outcomes
 A1.1 Calcula (utilitzant eines quantitatives com equacions diferencials i programes de resolució de les mateixes) paràmetres cinètics de sistemes de biocatalitzadors immobilitzats o no, si hi ha observacions experimentals adequades o prediu el comportament de biocatalitzadors immobilitzats si aquests paràmetres cinètics existeixen.
Fa servir eines matemàtiques per al disseny i predicció d'operació de bioreactors amb biocatalitzadors immobilitzats o no i per al disseny i selecció de seqüències de separació i purificació en bioprocessos.
Aplica correctament els balanços de matèria i energia, biotecnologia, transferència de matèria, operacions de separació, enginyeria de la reacció química, disseny de reactors, i valorització i transformació de matèries primeres i recursos energètics.
Type B Code Learning outcomes
Type C Code Learning outcomes
 C1.4 Produce grammatically correct written texts
Produce well-structured, clear and rich written texts
Produce written texts that are appropriate to the communicative situation

Contents
Topic Sub-topic
1. Bioprocesses: White, green, blue and red biotechnology. Sustainability, green chemistry, and biocatalysis. The economics of bioprocesses, bioethics and legislation.

2. Flowsheeting of the typical bioprocess. Reaction and separation processes.
3. Bioreactor and implications of biocatalysts in their design. 3.1. Categories of bioreactors. Batch vs. Continuous. Mass and energy balances.
3.2. Immobilised biocatalysts. Mathematical analysis. The basic problem: mass transport coupled with reaction.
3.3. Enzymatic reactors: kinetics and design or analysis considerations. Reactors with immobilised enzymes.
3.4. Cell bioreactors: kinetics, microbial and animal cell bioreactors.
4. Separation and purification processes of special interest in Biotechnology. 4.1 Centrifugation
4.2 Membrane processes
4.3 Chromatographies
5. Nutritional media development.
6. Scale-up in bioprocesses
7. Genetic engineering applications in bioprocesses.
8. Applications of bioprocesses: water treatment, pharmaceuticals, fermentations.

Planning
Methodologies  ::  Tests
  Competences (*) Class hours
Hours outside the classroom
(**) Total hours
Introductory activities
A1.1
C1.4
1 1 2
Case study
A1.1
C1.4
20 40 60
Problem solving, exercises
A1.1
15 22.5 37.5
Lecture
A1.1
15 6.5 21.5
Personal tuition
A1.1
C1.4
1 1 2
 
Objective short-answer tests
A1.1
C1.4
2 3 5
Extended-answer tests
A1.1
C1.4
1 9 10
Practical tests
A1.1
C1.4
5 5 10
Oral tests
A1.1
C1.4
0.5 1.5 2
 
(*) On e-learning, hours of virtual attendance of the teacher.
(**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.

Methodologies
Methodologies
  Description
Introductory activities Information on the course, the teaching and evaluation methods.
Case study Each subject of the course is introduced as a case study (description of a problem or situation). The case is known beforehand and the students propose solutions in class. Once the more appropriate components of the solution are decided, generalisations are made on the subject matter.
Problem solving, exercises A series of problems is distributed on each subject. Students are requested to hand in the solutions and some of them are discussed in class.
Lecture In lecture classes additional information is introduced on each subject and it is made sure that the generalisations of the conclusions of the case studies are correctly applied.
Personal tuition During "personal attention" rather than "tuition" any doubts that remain are discussed and the project development if followed with the help of the professor.

Personalized attention
Description
The professors are available in their office to discuss doubts on the problems, case studies, grading and project. The hour of attention will be announced the first day of class.

Assessment
Methodologies Competences Description Weight        
Case study
A1.1
C1.4
The description of each case study is known beforehand and is developed in class by the students. The contribution of each student is evaluated by means of a report that is handed to the professor before the class starts. This report is given a grade based on the effort rather than the "correctness" of the content. 10
Problem solving, exercises
A1.1
Five series of problems are distributed and should be resolved outside the classroom. Some problems are corrected randomly from each series and the grade obtained os the result of this evaluation part. 5
Objective short-answer tests
A1.1
C1.4
An exam with questions on all the subject matter will be part of the continuous evaluation. The exam will last for two hours and a grade of 4/10 in necessary in order to pass the course.
50
Extended-answer tests
A1.1
C1.4
The students will form teams and will develop a biotechnological design project. The report of this project will be evaluated with the same grade for all the team. The criteria for the grade will be the degree of innovation and the accuracy of the solution.
20
Practical tests
A1.1
C1.4
Five problem hour sessions will consist of handouts developed and returned during the session. 10
Oral tests
A1.1
C1.4
The presentation and defense of of the project results in an individual grade for each team member based on the format of the presentation, its content and the capacity to answer questions.
5
Others  
 
Other comments and second exam session

The best 80% of Handouts, case reports, and problem solutions will be taken into account for the final grade. This method ensures that students can learn through the evaluation process and also serves to recover missed activities due to ilness or other circumstances.

The second call exam permits to improve only the grade of the continuous evaluation exam, not the grade of the problems, handouts or case study reports.

During the exams there will be no mobile phones or other communication devices allowed nor the connection to the internet.


Sources of information

Basic M.L. Shuler, F. Kargi, Bioprocess Engineering: Basic Concepts , 2a, 2001
I.J. Duna, E. Heinzle, J. Ingham, J.E. Prenosil, Biological Reaction Engineering: Dynamic Modelling Fundamentals with Siumulation Examples , 2a, 2000

Differential equations solutions programme Madonna: http://www.berkeleymadonna.com/

Complementary

Recommendations


Subjects that it is recommended to have taken before
MATHEMATICS I/20214005
MATHEMATICS II/20214006
(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.