Because the supramolecular chemistry is based on the establishment of "non-covalent" interactions among molecules, this subject will describe different types of intermolecular forces based on examples of chemical and biological systems. Very commonly used concepts in supramolecular chemistry will are also be introduced as molecular recognition, alosterisme, cooperativity, self-assembly, dynamic libraries etc.. using examples from both purely organic and metal-organic systems. We will describe the application of supramolecular chemistry in the design and synthesis of functional molecular devices, as well as in the preparation of nanostructured molecular materials.
Competences
Type A
Code
Competences Specific
Research
AR5
Knowledge of the fundamental properties of intermolecular forces and their importance in chemistry, biology and materials science.
AR6
Learning how to apply concepts of supramolecular chemistry to the design and synthesis of molecular receptors, molecular devices and molecularly nanostructured materials.
AR7
Learning to interpret how chemical and biological processes operate on the basis of intermolecular interactions.
AR8
Understanding the experimental methods used in the characterization of supramolecular systems.
Type B
Code
Competences Transversal
Research
BR2
Treballar de manera autònoma amb iniciativa.
BR5
Presa de decisions.
BR10
Critical abilities: analysis and syntesis.
Type C
Code
Competences Nuclear
Common
Research
CR1
Comunicar-se de manera efectiva en la pràctica professional i com a ciutadà.
Learning aims
Objectives
Competences
Knowledge of the fundamental properties of intermolecular forces and their importance in chemistry, biology and materials science.
AR5
Learning how to apply concepts of supramolecular chemistry to the design and synthesis of molecular receptors, molecular devices and molecularly nanostructured materials.
AR6
BR2 BR5
Learning to interpret how chemical and biological processes operate on the basis of intermolecular interactions.
AR7
Understanding the experimental methods used in the characterization of supramolecular systems.
AR8
BR10
CR1
Contents
Topic
Sub-topic
Tema 1.
From molecular chemistry to supramolecular chemistry. Non-covalent interactions.
Tema 2.
Complementarity, induced fit, allosterism and cooperativity. Receptors and carriers. Dynamic processes: kinetics vs. thermodynamics.
Tema 3.
Ion recognition. Crown ethers, cryptands, cyclophanes, other receptors. Chiral recognition.
Tema 4.
A view of the hydrophobic effect. Hydrophobic interactions in molecular recognition.
Tema 5.
Supramolecular catalysis. Basic principles. Acceleration and turnover. Transition state recognition. Enzyme models.
Tema 6.
Confinement effects in catalysis. Micelles, vesicles, capsules. Catalytic antibodies and polymer imprinting. Autocatalysis: self-replicating systems.
Tema 7.
Molecular recognition of bio-molecules-1. Amino acids, peptides, proteins. Ligand-protein and protein-protein interactions.
Tema 8.
Molecular recognition of bio-molecules-2. Nucleobases, nucleotides and nucleic acids. DNA-ligand interactions. Intercalation. Recognition of carbohydrates.
Tema 9.
Self-assembly and self-organization.
Tema 10.
Self-assembly in synthetic systems.
Tema 11.
Dynamic combinatorial chemistry and supramolecular chirality.
Tema 12.
Molecular materials and devices.
Tema 13.
Hierarchical self-assembly. Monolayers and multilayers. Liquid crystals. Thermotropic and lyotropic systems. Mesophases. Phase diagrams. LC displays.
Tema 14.
Charge-transfer systems. Organic insulators, semiconductors, and conductors. Non-linear optics. Concepts. Dipolar and octupolar molecules. NLO devices.
Tema 15.
Experimental methods in supramolecular chemistry. Stoichiometry and binding constant. NMR titrations. Other methods. Aggregation and transport.
Tema 16.
Photo physics of Supramolecular Systems. Basic Principles. Photo physics of Supramolecular Advanced Concepts.
Tema 17.
Applications of luminescent supramolecular systems.
Hetero Supramolecular Chemistry.
Supramolecular systems for light to electric energy conversion. Part 1.
Supramolecular systems for light to electric energy conversion. Part 2.
Supramolecular Organic Field Effect Transistors.
Future perspectives on Functional Supramolecular Devices.
(*) On e-learning, hours of virtual attendance of the teacher. (**) The information in the planning table is for guidance only and does not take into account the heterogeneity of the students.
A presentation of the course and two introductory keynote sessions will be taught to describe the different types of intermolecular forces and other fundamental concepts for this topic.
Lecture
Lecture sessions showing the contents of items that comprise the course. The lectures will be supported by audiovisual media. Presentations “power-point" with videos and animation. Students will have a pdf document of each class on a CD compilation of the course, include also the research papers for recommended reading.
Assignments
In order to encourage learning, not just related to specific skills but also the general and transversal competences, the students should perform a group work. Each group must submit a report of the work and make an oral presentation of it. The theme of the work must be agreed with the lecturers of the subject.
Problem solving, classroom exercises
Formulation, analysis, discussion and resolution of problems or exercises. The student should work on them beforehand and the discussion is in class.
Personalized attention
Personal tuition
Description
Meetings with students either individually or in small groups to answer questions, indicate areas of improvement and guide the overall development of the subject.
Assessment
Description
Weight
Assignments
All students will be assigned with producing a written scientific report and deliver an oral presentation of his/her work. The topic of the assignment has to be related to Supramolecular Chemistry or nanochemistry and should be agreed with the supervisor of the work.
Reading assignments will also be given all along the course. The reading assignment will primarily consist in research articles related to the topics presented in the lecture.
50
Problem solving, classroom exercises
Formulation, analysis, discussion and resolution of problems or exercises. The student has worked out these problems beforehand and the discussion is in class.
10
Extended-answer tests
Written Exam
15
Objective multiple-choice tests
Learning is not a passive activity. Students should be actively engaged in the course by asking questions offering thoughts. Active engagement on the subject will contribute 5% to your final grade.
5
Others
Assistència, interès i participació a classe
20
Other comments and second exam session
Sources of information
Basic
STEED, J. W.; ATWOOD, J. L., Supramolecular Chemistry, John Wiley & Sons, 2000
Core Concepts in Supramolecular
Chemistry and Nanochemistry (Paperback)
by Jonathan W. Steed, David R. Turner and Karl Wallace.
·
Paperback: 320 pages
·
Publisher: Wiley; 1 edition (June 15, 2007)
·
Language: English
·
ISBN-10: 0470858672
·
ISBN-13: 978-0470858677
Complementary
SCHNEIDER, H.-J.; YATSIMIRSKY, A. K., Principles and methods in Supramolecular Chemistry, John Wiley & Sons, 2000
LEHN, J.-M., Supramolecular Chemistry Concepts and Perspective, VCH, 1995
VÖGTLE, F., Supramolecular Chemistry, John Wiley & Sons, 1991
, Comprehensive Supramolecular Chemistry (11 volums), Elsevier,
Recommendations
Other comments
This course introduces the student into the study of intermolecular interactions and their application in the development of molecular receptors, molecular materials and molecular devices. It is therefore a set of new concepts scarcely studied in other subjects. It is expected that the student has a good predisposition for reading research papers so as to perform the recommended exercises.
(*)The teaching guide is the document in which the URV publishes the information about all its courses. It is a public document and cannot be modified. Only in exceptional cases can it be revised by the competent agent or duly revised so that it is in line with current legislation.
STEED, J. W.; ATWOOD, J. L., Supramolecular Chemistry, John Wiley & Sons, 2000![]("file:///D:/DOCUME%7E1/Xavier/CONFIG%7E1/Temp/msohtml1/01/clip_image002.jpg")