| Guia docent Facultat de Química |
català |
| Grau en Bioquímica i Biologia Molecular (2009) |
 Assignatures |
| SENYALITZACIÓ I CONTROL DE FUNCIONAMENT CEL·LULAR |
| Continguts |
| DADES IDENTIFICATIVES | 2023_24 |
| Assignatura | SENYALITZACIÓ I CONTROL DE FUNCIONAMENT CEL·LULAR | Codi | 13214115 | |||||
| Ensenyament |
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Cicle | 1r | |||||
| Descriptors | Crèd. | Tipus | Curs | Període | ||||
| 6 | Obligatòria | Segon | 2Q |
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| Competències | Resultats d'aprenentage | Continguts |
| Planificació | Metodologies | Atenció personalitzada |
| Avaluació | Fonts d'informació | Recomanacions |
| Tema | Subtema |
| 1 Introduction: Need to control cell function. Mechanisms to control cell function. Basic principles of cell signalling. Extracellular signals. |
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| 2. Principles and Mechanisms of Protein Interactions. Properties of protein-protein interactions. Protein interactions in their cellular and molecular context |
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| 3. Signalling Enzymes. Enzymes and allosteric conformational changes. Protein phosphorylation G protein signalling. Signalling enzyme cascades |
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| 4. Receptors. Introduction General characteristics of receptors. Types of receptors. Ion channel linked. G protein-coupled ( GPCRs). Containing intrinsic enzymatic activity. Tyrosine kinase linked. Intracellular. Non-receptor perception. Receptor sensitivity and receptor density |
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| 5. Post-translational modifications in signalling. The logic of post-translational regulation. Addition of ubitiquin and related proteins. Histone acetylation and methylation |
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| 6. Subcellular location of signalling molecules. Localization as a signalling currency. Control of nuclear Localization. Control of Membrane Localization. Modulation of signalling by Membrane trafficking |
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| 7. Second Messengers: small signalling mediators. Properties of small signalling mediators. Classes of small signalling mediators. Calcium signalling. Specificity and regulation |
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| 8. Receptors nuclears: Ligands of Nuclear Receptors (NRs). Principles of signal transduction by transmembrane receptors and nuclear receptors. Structure of Nuclear Receptors. Transcriptional regulation by NRs Regulation of Signalling by NRs. Subcellular location of NRs. Nongenomic functions of NRs and their ligands |
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| 9. Redox signaling. NO. ROS | |
| 10.Information Processing by Signaling Devices and Networks. Characteristics of signal transduction. Signaling systems as information-processing devices. Integrating multiple signaling inputs. Responding to the strength or duration of an input. Modifying the strength of duration of output |
